Study carbon-based compounds and reactions

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Curriculum

What You'll Learn

01 Introduction to Organic Chemistry
4 topics
1 History and Development of Organic Chemistry
  • Early Theories and Vitalism
  • Key Discoveries and Scientists
  • Modern Organic Chemistry
2 Carbon: The Central Element
  • Electronic Configuration and Hybridization
  • Covalent Bonding and Carbon Compounds
  • Structural Diversity of Carbon
3 Structural Theory
  • Lewis Structures
  • Formal Charge
  • Resonance Theory
4 Nomenclature Principles
  • IUPAC Naming System
  • Common Names and Trade Names
  • Naming Conventions for Different Functional Groups
02 Chemical Bonding and Molecular Structure
4 topics
1 Atomic Orbitals and Molecular Orbitals
  • Atomic Orbital Theory
  • Molecular Orbital Theory
  • Hybridization (sp, sp², sp³)
2 Valence Bond Theory
  • Sigma and Pi Bonds
  • Bond Length and Bond Energy
  • Bond Polarity and Electronegativity
3 Molecular Geometry
  • VSEPR Theory
  • Structural Isomerism
  • Conformational Analysis
4 Intermolecular Forces
  • Van der Waals Forces
  • Hydrogen Bonding
  • Dipole-Dipole Interactions
  • Effects on Physical Properties
03 Stereochemistry
5 topics
1 Isomerism
  • Constitutional Isomers
  • Stereoisomers
  • Conformational Isomers
2 Chirality and Optical Activity
  • Chiral Centers and Molecules
  • Enantiomers and Diastereomers
  • Optical Rotation and Polarimetry
3 R and S Configuration
  • Cahn-Ingold-Prelog Rules
  • Assignment of R/S Configuration
  • Fischer Projections
4 Meso Compounds
  • Properties of Meso Compounds
  • Identification of Meso Structures
  • Symmetry Elements
5 Stereochemistry in Reactions
  • Stereoselective Reactions
  • Stereospecific Reactions
  • Resolution of Enantiomers
04 Alkanes and Cycloalkanes
4 topics
1 Structure and Properties
  • Homologous Series
  • Physical Properties and Trends
  • Conformational Analysis
2 Nomenclature
  • Naming Straight-Chain Alkanes
  • Naming Branched Alkanes
  • Naming Cycloalkanes
3 Reactions of Alkanes
  • Combustion
  • Halogenation
  • Free Radical Mechanisms
4 Cycloalkanes
  • Ring Strain and Stability
  • Conformations of Cycloalkanes
  • Polycyclic Systems
05 Alkenes and Alkynes
5 topics
1 Structure and Properties
  • Double and Triple Bonds
  • Geometry of Alkenes (E/Z System)
  • Physical Properties
2 Nomenclature
  • Naming Alkenes
  • Naming Alkynes
  • Naming Compounds with Multiple Unsaturations
3 Preparation of Alkenes and Alkynes
  • Elimination Reactions
  • Dehydration of Alcohols
  • Dehydrohalogenation
4 Reactions of Alkenes
  • Electrophilic Addition Reactions
  • Markovnikov's Rule
  • Hydration and Hydroxylation
  • Hydrogenation
  • Halogenation and Halohydrin Formation
  • Oxidation Reactions
  • Polymerization
5 Reactions of Alkynes
  • Electrophilic Addition
  • Hydration (Keto-Enol Tautomerism)
  • Reduction Reactions
  • Acidity of Terminal Alkynes
06 Aromatic Compounds
4 topics
1 Benzene and Aromaticity
  • Historical Development
  • Structure of Benzene
  • Resonance Energy
2 Hückel's Rule
  • 4n+2 Pi Electron Systems
  • Aromatic, Antiaromatic, and Nonaromatic Compounds
  • Heterocyclic Aromatic Compounds
3 Nomenclature of Aromatic Compounds
  • Monosubstituted Benzenes
  • Disubstituted Benzenes (Ortho, Meta, Para)
  • Polysubstituted Benzenes
  • Fused Ring Systems
4 Reactions of Aromatic Compounds
  • Electrophilic Aromatic Substitution
  • Directing Effects and Reactivity
  • Nucleophilic Aromatic Substitution
  • Side Chain Reactions
07 Alkyl Halides and Nucleophilic Substitution
5 topics
1 Structure and Properties
  • Types of Alkyl Halides
  • Physical Properties
  • Bond Polarity and Reactivity
2 Preparation of Alkyl Halides
  • From Alcohols
  • From Alkenes
  • Free Radical Halogenation
3 Nucleophilic Substitution Reactions
  • SN2 Mechanism
  • SN1 Mechanism
  • Factors Affecting SN1 and SN2 Reactions
4 Elimination Reactions
  • E1 Mechanism
  • E2 Mechanism
  • Competition Between Substitution and Elimination
5 Organometallic Compounds
  • Grignard Reagents
  • Organolithium Compounds
  • Applications in Synthesis
08 Alcohols, Phenols, and Ethers
6 topics
1 Structure and Properties
  • Classification of Alcohols
  • Hydrogen Bonding Effects
  • Acidity and Basicity
2 Nomenclature
  • Naming Alcohols
  • Naming Phenols
  • Naming Ethers
3 Preparation of Alcohols
  • From Alkenes
  • Reduction of Carbonyl Compounds
  • Grignard Reactions
4 Reactions of Alcohols
  • Oxidation
  • Dehydration
  • Conversion to Alkyl Halides
  • Esterification
5 Phenols
  • Acidity of Phenols
  • Electrophilic Substitution Reactions
  • Oxidation of Phenols
6 Ethers
  • Preparation of Ethers
  • Reactions of Ethers
  • Crown Ethers and Their Applications
09 Aldehydes and Ketones
5 topics
1 Structure and Properties
  • Carbonyl Group
  • Physical Properties
  • Spectroscopic Characteristics
2 Nomenclature
  • Naming Aldehydes
  • Naming Ketones
  • Common Names
3 Preparation of Aldehydes and Ketones
  • Oxidation of Alcohols
  • Ozonolysis of Alkenes
  • Friedel-Crafts Acylation
  • Hydration of Alkynes
4 Reactions of Aldehydes and Ketones
  • Nucleophilic Addition
  • Formation of Acetals and Ketals
  • Reactions with Nitrogen Nucleophiles
  • Oxidation and Reduction
  • Aldol Condensation
  • Cannizzaro Reaction
5 Alpha Carbon Chemistry
  • Acidity of Alpha Hydrogens
  • Keto-Enol Tautomerism
  • Halogenation at the Alpha Position
10 Carboxylic Acids and Derivatives
6 topics
1 Structure and Properties
  • Carbonyl Group and Acidity
  • Hydrogen Bonding
  • Physical Properties
2 Nomenclature
  • Naming Carboxylic Acids
  • Naming Acid Derivatives
  • Common Names
3 Preparation of Carboxylic Acids
  • Oxidation of Alcohols and Aldehydes
  • Carbonation of Grignard Reagents
  • Hydrolysis of Nitriles
4 Reactions of Carboxylic Acids
  • Acid-Base Reactions
  • Nucleophilic Acyl Substitution
  • Reduction
  • Decarboxylation
5 Derivatives of Carboxylic Acids
  • Acid Halides
  • Acid Anhydrides
  • Esters
  • Amides
  • Nitriles
6 Comparative Reactivity of Acid Derivatives
  • Relative Reactivity in Nucleophilic Acyl Substitution
  • Hydrolysis Reactions
  • Reduction Reactions
11 Amines and Nitrogen-Containing Compounds
6 topics
1 Structure and Properties
  • Classification of Amines
  • Bonding and Hybridization
  • Physical Properties
2 Nomenclature
  • Naming Primary, Secondary, and Tertiary Amines
  • Naming Quaternary Ammonium Salts
  • Common Names
3 Basicity of Amines
  • Factors Affecting Basicity
  • Comparison with Other Nitrogen Compounds
  • Effect of Substituents
4 Preparation of Amines
  • Reduction of Nitro Compounds
  • Reductive Amination
  • Gabriel Synthesis
  • Hofmann Rearrangement
5 Reactions of Amines
  • Alkylation and Acylation
  • Reaction with Nitrous Acid
  • Hofmann Elimination
  • Cope Elimination
6 Heterocyclic Amines
  • Pyridine, Pyrrole, and Imidazole
  • Quinoline and Isoquinoline
  • Indole and Purine Systems
  • Biological Significance
12 Spectroscopic Methods in Organic Chemistry
6 topics
1 Principles of Spectroscopy
  • Electromagnetic Spectrum
  • Absorption and Emission
  • Quantization of Energy
2 Infrared (IR) Spectroscopy
  • Theory and Instrumentation
  • Functional Group Analysis
  • Interpretation of IR Spectra
3 Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Principles of NMR
  • Chemical Shift
  • Spin-Spin Coupling
  • ¹H NMR Spectroscopy
  • ¹³C NMR Spectroscopy
  • 2D NMR Techniques
4 Mass Spectrometry
  • Principles and Instrumentation
  • Fragmentation Patterns
  • Interpretation of Mass Spectra
5 Ultraviolet-Visible (UV-Vis) Spectroscopy
  • Electronic Transitions
  • Chromophores and Auxochromes
  • Applications in Structure Determination
6 Combined Applications in Structure Determination
  • Strategy for Structure Elucidation
  • Case Studies
  • Problem-Solving Approaches
13 Carbohydrates
5 topics
1 Classification and Nomenclature
  • Monosaccharides
  • Disaccharides
  • Polysaccharides
2 Stereochemistry of Carbohydrates
  • D and L Configuration
  • Fischer Projections
  • Haworth Structures
3 Reactions of Monosaccharides
  • Mutarotation
  • Glycoside Formation
  • Oxidation and Reduction
  • Osazone Formation
4 Disaccharides and Polysaccharides
  • Glycosidic Linkages
  • Common Disaccharides (Maltose, Lactose, Sucrose)
  • Structural Polysaccharides (Cellulose, Chitin)
  • Storage Polysaccharides (Starch, Glycogen)
5 Biological Importance
  • Energy Storage and Supply
  • Cell Recognition and Communication
  • Structural Components
14 Amino Acids, Peptides, and Proteins
5 topics
1 Amino Acids
  • Structure and Classification
  • Stereochemistry
  • Acid-Base Behavior
  • Isoelectric Point
2 Peptide Bond
  • Structure and Properties
  • Peptide Synthesis
  • Protection and Deprotection Strategies
3 Protein Structure
  • Primary Structure
  • Secondary Structure (α-Helix, β-Sheet)
  • Tertiary Structure
  • Quaternary Structure
4 Protein Function
  • Enzymes as Catalysts
  • Transport Proteins
  • Structural Proteins
  • Defense Proteins
5 Protein Analysis
  • Sequencing Techniques
  • X-ray Crystallography
  • NMR Studies of Proteins
15 Lipids
5 topics
1 Classification and Structure
  • Fatty Acids
  • Waxes
  • Triglycerides
  • Phospholipids
  • Steroids
2 Properties of Lipids
  • Solubility
  • Melting Points and Physical States
  • Amphipathic Nature
3 Biological Membranes
  • Lipid Bilayers
  • Membrane Fluidity
  • Membrane Proteins
4 Lipid Metabolism
  • Fatty Acid Oxidation
  • Fatty Acid Synthesis
  • Cholesterol Biosynthesis
5 Biological Significance
  • Energy Storage
  • Cell Signaling
  • Hormonal Functions
16 Nucleic Acids
5 topics
1 Components of Nucleic Acids
  • Nitrogenous Bases
  • Pentose Sugars
  • Phosphate Groups
2 Nucleosides and Nucleotides
  • Structure and Nomenclature
  • N-Glycosidic Bond
  • Phosphodiester Bond
3 DNA Structure
  • Primary Structure
  • Double Helix
  • Base Pairing
  • Major and Minor Grooves
4 RNA Structure
  • Types of RNA
  • Secondary and Tertiary Structures
  • Comparison with DNA
5 Nucleic Acid Function
  • DNA Replication
  • Transcription
  • Translation
  • Gene Expression
17 Organic Synthesis Strategies
5 topics
1 Principles of Synthesis Design
  • Retrosynthetic Analysis
  • Disconnection Approach
  • Synthetic Equivalents
2 Carbon-Carbon Bond Formation
  • Grignard and Organolithium Reactions
  • Aldol and Related Reactions
  • Wittig Reaction
  • Diels-Alder Reaction
3 Functional Group Interconversions
  • Oxidation Strategies
  • Reduction Strategies
  • Protection/Deprotection Methods
4 Selectivity in Organic Synthesis
  • Chemoselectivity
  • Regioselectivity
  • Stereoselectivity
5 Modern Synthetic Methods
  • Organometallic Catalysts
  • Cross-Coupling Reactions
  • Asymmetric Synthesis
  • Green Chemistry Approaches
18 Pericyclic Reactions
5 topics
1 Molecular Orbital Theory in Pericyclic Reactions
  • Frontier Molecular Orbitals
  • HOMO-LUMO Interactions
  • Conservation of Orbital Symmetry
2 Cycloaddition Reactions
  • [2+2] Cycloadditions
  • [4+2] Cycloadditions (Diels-Alder)
  • 1,3-Dipolar Cycloadditions
3 Electrocyclic Reactions
  • Conrotatory and Disrotatory Processes
  • Woodward-Hoffmann Rules
  • Synthetic Applications
4 Sigmatropic Rearrangements
  • [1,j] Shifts
  • [i,j] Shifts
  • Cope and Claisen Rearrangements
5 Ene Reactions
  • Mechanism
  • Stereochemistry
  • Applications
19 Heterocyclic Chemistry
5 topics
1 Three-Membered Heterocycles
  • Epoxides
  • Aziridines
  • Thiiranes
2 Five-Membered Heterocycles
  • Furan
  • Pyrrole
  • Thiophene
  • Imidazole and Oxazole
3 Six-Membered Heterocycles
  • Pyridine
  • Pyrimidine
  • Pyran
  • Piperidine
4 Fused Heterocycles
  • Indole and Isoindole
  • Quinoline and Isoquinoline
  • Purine and Pteridine
  • Benzofuran and Benzothiophene
5 Biological and Pharmaceutical Significance
  • Heterocycles in Natural Products
  • Heterocycles in Drug Design
  • Structure-Activity Relationships
20 Organic Reaction Mechanisms
6 topics
1 Kinetics and Thermodynamics
  • Rate Laws and Order
  • Transition State Theory
  • Energy Diagrams
2 Reaction Intermediates
  • Carbocations
  • Carbanions
  • Free Radicals
  • Carbenes and Nitrenes
3 Substitution Mechanisms
  • SN1 and SN2
  • SNAr
  • SE and SEAr
4 Elimination Mechanisms
  • E1 and E2
  • E1cB
  • Hofmann and Zaitsev Products
5 Addition Mechanisms
  • Electrophilic Additions
  • Nucleophilic Additions
  • Free Radical Additions
6 Rearrangement Mechanisms
  • Carbocation Rearrangements
  • Neighboring Group Participation
  • Fragmentations
21 Natural Products Chemistry
5 topics
1 Isolation and Characterization
  • Extraction Techniques
  • Chromatographic Methods
  • Structural Elucidation
2 Terpenes and Terpenoids
  • Isoprene Rule
  • Classification
  • Biosynthesis
  • Representative Structures
3 Alkaloids
  • Classification
  • Biosynthetic Pathways
  • Biological Activities
  • Important Alkaloid Families
4 Polyketides
  • Biosynthesis
  • Macrolides
  • Polyethers
  • Tetracyclines
5 Shikimic Acid Derivatives
  • Biosynthetic Pathway
  • Phenylpropanoids
  • Flavonoids
  • Lignans
22 Green Chemistry and Sustainable Organic Synthesis
5 topics
1 Principles of Green Chemistry
  • Atom Economy
  • Waste Prevention
  • Energy Efficiency
2 Alternative Reaction Media
  • Water as Solvent
  • Ionic Liquids
  • Supercritical Fluids
  • Solvent-Free Reactions
3 Catalysis in Green Chemistry
  • Homogeneous Catalysis
  • Heterogeneous Catalysis
  • Biocatalysis
  • Photocatalysis
4 Renewable Feedstocks
  • Biomass Conversion
  • Platform Chemicals
  • Biopolymers
5 Green Metrics and Assessment
  • E-Factor and Process Mass Intensity
  • Life Cycle Assessment
  • Sustainability Metrics
23 Medicinal Chemistry
5 topics
1 Drug Discovery Process
  • Target Identification
  • Lead Compound Discovery
  • Lead Optimization
  • Clinical Trials
2 Pharmacokinetics and Pharmacodynamics
  • Absorption, Distribution, Metabolism, Excretion (ADME)
  • Drug-Receptor Interactions
  • Structure-Activity Relationships
3 Drug Design Strategies
  • Rational Drug Design
  • Computer-Aided Drug Design
  • Fragment-Based Drug Design
  • Prodrug Approach
4 Case Studies of Important Drug Classes
  • Antibiotics
  • Anti-inflammatory Drugs
  • Cardiovascular Drugs
  • Anticancer Agents
  • Central Nervous System Drugs
5 Recent Advances
  • Targeted Therapies
  • Biologics and Biosimilars
  • Personalized Medicine
24 Organometallic Chemistry
5 topics
1 Metal-Carbon Bonds
  • Nature and Properties
  • Stability and Reactivity
  • Classification of Organometallic Compounds
2 Main Group Organometallics
  • Organolithium Compounds
  • Grignard Reagents
  • Organoboranes
  • Organosilicon Compounds
3 Transition Metal Organometallics
  • 18-Electron Rule
  • Ligand Classification
  • Common Transition Metal Complexes
  • Metallocene Compounds
4 Organometallic Reactions
  • Oxidative Addition
  • Reductive Elimination
  • Transmetallation
  • Migratory Insertion
  • β-Hydride Elimination
5 Catalytic Applications
  • Homogeneous Catalysis
  • Cross-Coupling Reactions
  • Olefin Metathesis
  • Hydroformylation
  • Asymmetric Catalysis
25 Polymer Chemistry
5 topics
1 Polymer Basics
  • Classification of Polymers
  • Nomenclature
  • Molecular Weight and Distribution
2 Polymerization Mechanisms
  • Step-Growth Polymerization
  • Chain-Growth Polymerization
  • Ring-Opening Polymerization
  • Living Polymerization
3 Structure and Properties
  • Crystallinity and Morphology
  • Thermal Properties
  • Mechanical Properties
  • Solution Properties
4 Common Synthetic Polymers
  • Polyolefins
  • Polyesters
  • Polyamides
  • Polyurethanes
  • Acrylic Polymers
5 Advanced Polymer Materials
  • Conducting Polymers
  • Biodegradable Polymers
  • Responsive Polymers
  • Block Copolymers
  • Polymer Composites
26 Physical Organic Chemistry
5 topics
1 Thermodynamics in Organic Chemistry
  • Enthalpy, Entropy, and Free Energy
  • Equilibrium Constants
  • Group Additivity
2 Chemical Kinetics
  • Rate Laws and Mechanisms
  • Linear Free Energy Relationships
  • Hammett and Taft Equations
3 Isotope Effects
  • Primary Kinetic Isotope Effects
  • Secondary Kinetic Isotope Effects
  • Applications in Mechanism Studies
4 Solvent Effects
  • Polarity and Polarizability
  • Hughes-Ingold Rules
  • Specific and Non-specific Solvation
5 Quantum Mechanical Applications
  • Molecular Orbital Calculations
  • Computational Methods
  • Structure-Reactivity Predictions
27 Supramolecular Chemistry
5 topics
1 Non-Covalent Interactions
  • Hydrogen Bonding
  • π-π Interactions
  • Electrostatic Interactions
  • Van der Waals Forces
2 Host-Guest Chemistry
  • Molecular Recognition
  • Complementarity Principles
  • Binding Constants and Thermodynamics
3 Supramolecular Assemblies
  • Crown Ethers and Cryptands
  • Cyclodextrins
  • Calixarenes
  • Catenanes and Rotaxanes
4 Self-Assembly Processes
  • Micelles and Vesicles
  • Liquid Crystals
  • Molecular Machines
  • Metal-Organic Frameworks
5 Applications of Supramolecular Chemistry
  • Drug Delivery Systems
  • Sensors and Molecular Recognition
  • Catalysis
  • Nanotechnology
28 Photochemistry and Photophysics
5 topics
1 Light Absorption and Excited States
  • Electronic Transitions
  • Jablonski Diagrams
  • Fluorescence and Phosphorescence
2 Photochemical Reactions
  • Photoisomerization
  • Photocycloadditions
  • Photooxidation and Photoreduction
  • Photofragmentation
3 Photosensitization
  • Energy Transfer Processes
  • Electron Transfer Processes
  • Photosensitizers
4 Photochromism
  • Mechanisms of Photochromic Systems
  • Classes of Photochromic Compounds
  • Applications
5 Applied Photochemistry
  • Photovoltaics
  • Photocatalysis
  • Photodynamic Therapy
  • Photolithography
29 Bioorganic Chemistry
5 topics
1 Enzyme Mechanisms
  • Catalytic Strategies
  • Cofactors and Coenzymes
  • Enzyme Kinetics
2 Enzyme Inhibition
  • Reversible Inhibition
  • Irreversible Inhibition
  • Transition State Analogues
3 Biomimetic Chemistry
  • Synthetic Enzymes
  • Model Systems
  • Artificial Receptors
4 Chemical Biology
  • Bioorthogonal Chemistry
  • Activity-Based Protein Profiling
  • Chemical Genetics
5 Bioconjugation Techniques
  • Protein Modification
  • Nucleic Acid Conjugation
  • Click Chemistry Applications
  • Site-Specific Labeling
30 Advanced Analytical Techniques in Organic Chemistry
5 topics
1 Chromatographic Methods
  • High-Performance Liquid Chromatography
  • Gas Chromatography
  • Supercritical Fluid Chromatography
  • Chiral Separation Techniques
2 Advanced Mass Spectrometry
  • Tandem Mass Spectrometry
  • High-Resolution Mass Spectrometry
  • MALDI-TOF
  • LC-MS and GC-MS Hyphenated Techniques
3 Advanced NMR Techniques
  • Multidimensional NMR
  • Solid-State NMR
  • Dynamic NMR
  • NMR of Biological Macromolecules
4 X-ray Crystallography
  • Principles and Instrumentation
  • Structure Solution and Refinement
  • Absolute Configuration Determination
  • Protein Crystallography
5 Computational Methods
  • Molecular Dynamics
  • Quantum Chemical Calculations
  • Structure Prediction
  • Molecular Docking

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